mutational - significado y definición. Qué es mutational
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Qué (quién) es mutational - definición


Mutational signatures         
  • COSMIC]] Signature 18 described by Alexandrov et al<ref name="Alexandrov2013" /> (Signature 18 plot [https://github.com/eyzhao/mutation-signature-tools/tree/master/visualization R code]).<ref name="Zhao 2017" />
  • '''Conceptual workflow of somatic mutational signatures identification.''' Diverse mutagenesis processes shape the somatic landscape of tumors. Deciphering the underlying patterns of cancer mutations allows to uncover relationships between these recurrent patterns of mutations and infer possible causal mutational processes.
CHARACTERISTIC COMBINATION OF MUTATION TYPES ARISING FROM A SPECIFIC MUTAGENESIS PROCESS
User:Mylinhthibodeau/sandbox/Mutational Signatures in Cancer; Draft:Mutational Signatures in Cancer; Mutational Signatures in Cancer; Mutational signatures in cancer
Mutational signatures are characteristic combinations of mutation types arising from specific mutagenesis processes such as DNA replication infidelity, exogenous and endogenous genotoxin exposures, defective DNA repair pathways, and DNA enzymatic editing.
Tumor mutational burden         
  • Factors such as tumor cell content, tissue preprocessing, choice of sequencing technology, downstream bioinformatic pipelines, and TMB cutoffs can influence TMB calculations.
Tumour mutational burden (abbreviated as TMB) is a genetic characteristic of tumorous tissue that can be informative to cancer research and treatment. It is defined as the number of non-inherited mutations per million bases (Mb) of investigated genomic sequence, and its measurement has been enabled by next generation sequencing.
Puberphonia         
Puberphonia (also known as mutational falsetto, functional falsetto, incomplete mutation, adolescent falsetto, or pubescent falsetto) is a functional voice disorder that is characterized by the habitual use of a high-pitched voice after puberty, hence why many refer to the disorder as resulting in a ‘falsetto’ voice. The voice may also be heard as breathy, rough, and lacking in power.